Evidence map›Paper›PMID 41112615›Full record

ArticleWorld journal of psychiatry2025

Psychiatric sequelae following aneurysmal subarachnoid hemorrhage: Insights from a high-volume neurosurgical center in northern China.

Zhong-Xiao Wang, Xin-Yue Gao, Yun-Peng Cao, Ke-Xin Li

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Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Zhong-Xiao WangDepartment of Interventional Neuroradiology, Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. zx1994824@163.com.
Xin-Yue GaoClinical College, Capital Medical University, Beijing 100070, China.
Yun-Peng CaoClinical College, Capital Medical University, Beijing 100070, China.
Ke-Xin LiClinical College, Capital Medical University, Beijing 100070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAneurysmal subarachnoid hemorrhage (aSAH), a particularly devastating subtype of stroke, is associated with substantial rates of mortality and long-term functional impairment. Despite notable progress in therapeutic strategies, a considerable proportion of aSAH survivors continue to suffer from neuropsychiatric complications, most commonly anxiety and depression, which detrimentally impact their overall quality of life.

aimTo investigate the prevalence of anxiety and depressive symptoms in patients with aSAH and to identify associated clinical risk factors.

methodsClinical records of 1268 consecutive patients diagnosed with aSAH and treated between 2016 and 2022 were retrospectively reviewed. At follow-up, psychological assessments were performed using the Hospital Anxiety and Depression Scale to quantify symptoms of anxiety and depression. To identify independent predictors associated with these psychological outcomes post-aSAH, both univariate and multivariate statistical analyses were employed.

resultsAmong the studied cohort, 34.9% of patients presented with anxiety symptoms, while 31.8% demonstrated depressive features. Multivariate analysis identified female sex, presence of multiple aneurysms, a positive family history of cerebral hemorrhage, and receiving surgical clipping as independent predictors of anxiety. In contrast, significant predictors of depression included female sex, multiplicity of aneurysms, posterior circulation aneurysm localization, and poor clinical outcome. Notably, age above 60 years and documented functional recovery were associated with a reduced risk of depression.

conclusionAnxiety and depression are common neuropsychiatric sequelae in survivors of aSAH, each associated with a distinct set of risk factors. Early identification and targeted management of these risk profiles may facilitate more effective intervention strategies for psychological comorbidities, ultimately contributing to improved long-term patient outcomes.

Indexed as

Aneurysmal subarachnoid hemorrhageAnxietyDepressionPsychological outcomesRisk factors

Identifiers

PMID41112615
PMCPMC12531968

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