Trial reportWorld journal of psychiatry2025
Effect of preoperative transcranial direct current stimulation on postoperative delirium in elderly patients following laparoscopic surgery.
Trial report in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial
Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery
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7 authors.
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Abstract
backgroundPostoperative delirium (POD), an acute neuropsychiatric complication in elderly surgical patients, manifests as attention and cognitive disturbances that may last 24-72 hours after surgery, potentially progressing to dementia. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, enhances cortical excitability and cognitive function by modulating brain networks and synaptic plasticity. Elderly patients undergoing major laparoscopic surgery face elevated POD risks due to prolonged anesthesia and pneumoperitoneum-induced cerebral hypoperfusion. This study investigates whether pre-anesthesia tDCS can reduce POD incidence in this population.
aimTo investigate the effect of preoperative tDCS on reducing the incidence of POD in elderly patients undergoing major laparoscopic surgery.
methodsIn this study, we enrolled 220 elderly patients who underwent major laparoscopic surgery between April 2024 and December 2024. Patients were randomly assigned to the active-tDCS (group A) and sham-tDCS (group S) groups. A single session of tDCS or sham stimulation was administered 30 minutes before anesthesia induction. The primary outcome was the incidence of POD during within 3 days postoperatively.
resultsA total of 201 patients were included in the final analysis, with 100 patients in group A and 101 in group S. The incidence of POD within 3 days postoperatively was 7.0% in group A, which was significantly lower than 22.8% in group S. On postoperative day 1, the Self-Rating Anxiety Scale and Self-Rating Depression Scale scores significantly differed between the two groups, but the pain scores showed no significant difference.
conclusionA single session of preoperative tDCS can reduce the incidence of POD in elderly patients undergoing major laparoscopic surgery and can also reduce postoperative anxiety and depression in these patients.
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