ArticleWorld journal of psychiatry2025
Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Symptom Burden in Postural Orthostatic Tachycardia Syndrome (POTS) and Endometriosis: A Retrospective Cohort Study.Cureus · 2026Article
- Targeting Microglia-Neuron Crosstalk to Regulate Neuronal Excitability: Novel Translational Approaches for Chronic Pain Intervention.International journal of molecular sciences · 2026Review
- Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.International journal of molecular sciences · 2026Review
- Primary emotional systems and personality functioning in women with endometriosis receiving brief psychotherapy: a longitudinal study using ANPS and SWAP-200.Frontiers in psychology · 2026Article
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Authors and funding
4 authors.
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Abstract
backgroundEndometriosis affects approximately 10% of reproductive-age women and is frequently associated with chronic pelvic pain. Patients with endometriosis often experience comorbid depression and anxiety, but the underlying mechanisms connecting these conditions are unclear.
aimTo assess the prevalence of depression and anxiety in endometriosis patients and explore neuroimmune mechanisms mediated
methodsA retrospective cohort study was conducted with 200 patients with endometriosis-associated chronic pain from June 2020 to December 2024. Depression and anxiety were assessed using validated psychological instruments. Inflammation biomarkers interleukin (ILs) (IL-6, IL-1β), tumor necrosis factor-alpha, C-reactive protein, and brain-derived neurotrophic factor were measured in serum. Pain severity was assessed using visual analog scales. Correlation and regression analyses were performed to examine relationships between inflammatory markers, pain severity, and psychological outcomes.
resultsAmong the 200 patients, 42.5% exhibited clinically significant depression and 51.0% showed anxiety symptoms. Serum levels of IL-6, IL-1β, tumor necrosis factor-alpha, and C-reactive protein were significantly higher in patients with comorbid depression and anxiety compared with those without psychological symptoms (
conclusionOverall, the findings suggest that inflammatory factors mediate a neuroimmune mechanism linking endometriosis-associated chronic pain with depression and anxiety. Therapeutic targets for managing psychological comorbidities in patients with endometriosis through anti-inflammatory interventions should be explored, and an integrated treatment approach addressing both physical and psychological symptoms is emphasized.
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