Recurrent plasma cell myeloma with intracytoplasmic Auer rod-like inclusions after autologous hematopoietic stem cell transplantation.

Chenchen Niu, Elizabeth Brem, Ying Zhang, Dong Ren, Truc Tran, Ashley Gamayo, Xiaohui Zhao, Sherif A Rezk

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Article in International journal of clinical and experimental pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Chenchen NiuDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Elizabeth BremDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Ying ZhangDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Dong RenDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Truc TranDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Ashley GamayoDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Xiaohui ZhaoDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Sherif A RezkDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Medical Center Orange, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cell myeloma (PCM) is a bone marrow based neoplastic disorder of plasma cells. The presence of intracytoplasmic Auer rod-like inclusions (ARLIs) in PCM is exceedingly rare. To the best of our knowledge, approximately 40 cases have been published since its first description in 1940. These inclusions are predominantly observed in kappa-restricted, IgG-producing PCM. Only 7 cases of kappa-restricted, IgA-producing PCM with intracytoplasmic ARLIs have been documented in the literature. Here, we reported a rare case of recurrent kappa-restricted, IgA-positive PCM exhibiting intracytoplasmic ARLIs both before and after autologous hematopoietic stem cell transplantation (HSCT). The clinical features, laboratory studies, diagnosis, and management of this case were described. A comprehensive review of the literature was also provided to explore the origin and pathogenesis of these inclusions, and to examine their prognostic implications.

Indexed as

Auer rod-like inclusionsautologous hematopoietic stem cells transplantationPlasma cell myeloma

Identifiers

PMID41112523

DOI10.62347/OLMG7236

PMCPMC12531499

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