ArticleSurgical neurology international2025
Metastatic follicular thyroid carcinoma to the brain during pregnancy: A neurosurgical and ethical challenge.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intracranial metastases originating from differentiated thyroid carcinoma are rare, with follicular subtypes representing a minority of cases. Their manifestation during pregnancy is exceedingly rare and presents considerable neurosurgical, obstetric, and ethical challenges. This report describes a case of symptomatic brain metastasis from follicular thyroid carcinoma (FTC) in a pregnant patient who was successfully managed with surgical resection during her second trimester. Case Description: A 28-year-old woman presented with headache, vomiting, and visual disturbances at 19 weeks' gestation. Her medical history included papillary thyroid carcinoma, which was previously treated with total thyroidectomy, I-131 ablation (cumulative dose, 800 mCi), and external neck radiotherapy. Surveillance imaging performed during early pregnancy revealed pulmonary and submandibular lymph node metastases. The patient declined further oncological treatment due to her pregnancy. On admission, brain magnetic resonance imaging revealed a heterogeneous enhancing lesion in the right parieto-occipital region, accompanied by surrounding edema and midline shift, and two extracranial scalp lesions. Following a multidisciplinary evaluation, neurosurgical resection was performed under general anesthesia with continuous fetal monitoring. Gross total resection of both intracranial and extracranial tumors was achieved. Histopathological examination confirmed metastatic FTC. Postoperative recovery was uneventful, and the patient successfully completed her pregnancy. The patient succumbed to systemic oncologic progression in 2021. Conclusion: This case underscores the feasibility and safety of neurosurgical intervention for brain metastases during the second trimester of pregnancy, the importance of a multidisciplinary approach, and the urgent need for evidence-based guidelines to manage intracranial malignancies in pregnant patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.