Evidence map›Paper›PMID 41112352›Full record

ArticleAnnals of surgical treatment and research2025

The prognostic significance of the fibrinogen-to-albumin ratio in neuroblastoma: a retrospective cohort study.

Jian Sun, Peng Lu, Yao Zhang, Chao Yang, Xiaobin Deng

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Article in Annals of surgical treatment and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jian SunDepartment of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-8214-2827
Peng LuDepartment of Pediatrics, Women's and Children's Hospital, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0006-7407-7416
Yao ZhangDepartment of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-1489-3044
Chao YangDepartment of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-7023-3577
Xiaobin DengDepartment of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9972-0523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate the potential prognostic value of fibrinogen-to-albumin ratio (FAR) in patients with neuroblastoma (NB). Methods: We conducted a retrospective cohort study with 257 patients with NB included as the training group, and 78 patients included as the validation group. The associations between NB and clinicopathological categorical variables based on FAR were assessed. Survival time and the corresponding survival curve were analyzed using the Kaplan-Meier survival analysis. Univariate and multivariate Cox proportional hazard regression models were utilized to identify potential prognostic factors. A prognostic nomogram was constructed. The predictive performance of the nomogram was evaluated using calibration curves. Results: Based on the receiver operating characteristic analysis, the optimal cutoff value for FAR was found to be 0.0734. Both univariate and multivariate models demonstrated that FAR is a potential prognostic factor for overall survival in NB patients. Furthermore, the development of a nomogram based on the identified potential prognostic factors was predictive of the 3- and 5-year overall survival probabilities in both the training group and the validation group. Conclusion: FAR, a routinely performed test known for its simplicity, objectivity, and cost-effectiveness, has emerged as a promising prognostic factor in NB. Its potential applicability in clinical practice holds great promise.

Indexed as

FibrinogenNeuroblastomaPrognosisSerum albuminSurvival rate

Identifiers

PMID41112352
PMCPMC12531639

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