ArticleJournal of hepatocellular carcinoma2025
Hypoxia- and Anoikis-Related lncRNA Signature Defines Molecular Subtypes and Predicts Prognosis and Immunotherapy Response in Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
13 authors.
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Abstract
Background: Hepatocellular carcinoma (HCC) is characterized by high incidence and mortality rates, with hypoxia and anoikis resistance playing crucial roles in its progression and metastasis. While long non-coding RNA (lncRNA) significantly influence tumor biology, their roles in hypoxia-anoikis-resistant HCC remain unclear. Methods: This study utilized RNA-seq data and clinical information from the TCGA and GEO databases to analyze 154 hypoxia- and anoikis-related lncRNAs and identify differentially expressed candidates. Cluster analysis with Consensus Cluster Plus revealed links to clinical outcomes and genomic features. Tumor immune microenvironment and pathway enrichment were assessed using CIBERSORT and ssGSEA. A nine-gene risk model was developed via LASSO Cox regression and internally validated. Preliminary experimental assays suggested that the identified lncRNAs may influence apoptosis under hypoxia and anoikis conditions. Results: HCC patients were classified into two molecular subtypes, C1 and C2, with distinct prognostic outcomes and clinical features. These subtypes showed distinct immune infiltration characteristics and differential immunotherapy response scores. A nine-lncRNA prognostic model effectively predicted overall survival (OS), with the high-risk group showing increased immunosuppressive elements, such as Tregs and inactivated M0 macrophages, suggesting limited immunotherapy efficacy. Chemotherapy sensitivity analysis revealed varying drug responses between risk groups, while hypoxia- and anoikis-related lncRNAs, including Conclusion: Research has demonstrated that hypoxia- and anoikis-related lncRNAs serve as reliable biomarkers for predicting liver cancer prognosis and immunotherapy response, offering potential for developing novel therapeutic targets and strategies to enhance treatment outcomes and patient prognosis.
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