ArticleFrontiers in immunology2025
Genomic characterization of the T-cell receptor loci in
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Unique TCR loci architecture in newts: TRA and TRD separation inFrontiers in immunology · 2025Article
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8 authors.
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Abstract
Background: Amphibians are valuable models for comparative immunology. In the caudate Methods: T cell receptor loci were mapped and annotated in the Results: The T cell receptor alpha and delta locus in axolotl shows an overall conserved structure compared with other tetrapods. The alpha locus contained a higher number of variable genes than the beta and delta loci, with a predominance of functional genes (ratio 3.06). No gene encoding the pre-T cell receptor chain alpha was identified. The delta locus harbored two conventional variable genes, but no expression was detected in RNA sequencing data, suggesting pseudogenization. Neither delta chain diversity genes nor gamma chain elements were found in the genome or spleen transcriptome. The beta locus displayed structural similarity to that of other tetrapods and included five translocons with diversity, joining, and constant segments. One constant gene consisted of two exons encoding two constant domains. Functional variable genes predominated in the beta locus (ratio 3.6). Conclusion: Our study reveals conserved but distinctive features of axolotl T cell receptor loci, including restricted delta-chain diversity, absence of gamma chain and pre-T cell receptor alpha, and structural novelty in the beta locus. These findings provide new insights into the evolution of T cell receptors in amphibians and offer a genomic framework to explore the links between adaptive immunity and tissue regeneration in
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