SynthesisFrontiers in immunology2025
Global research trends in neurosyphilis: a bibliometric analysis from 2010 to 2024.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Case of Neuro- and Otosyphilis Successfully Managed with a Sequential Regimen Including Ceftriaxone.Infection and drug resistance · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neurosyphilis, as a serious infectious disease caused by Objective: Bibliometrics was adopted to analyze the research trends of neurosyphilis from 2010 to 2024, and to identify the core themes, hotspots and development directions. Methods: Research related to neurosyphilis from 2010 to 2024 was retrieved in the Web of Science core Collection (WOSCC). Bibliometrix, VOSviewer, CiteSpace, and BioBERT language models were employed to perform bibliometric and knowledge mapping analyses on global research output, author/institution collaboration networks, keyword evolution, co-citation clusters, and associated genes in the field of neurosyphilis. Results: A total of 863 articles were included in the analysis. From 2010 to 2024, both the number of publications and citations demonstrated a rapid upward trend. The United States and China were the leading contributors in the field of neurosyphilis research, accounting for 27.3% and 26.9% of global publications, respectively. The University of Washington and Xiamen University emerged as the most prolific research institutions. Keyword analysis identified " cerebrospinal fluid (CSF)," " human immunodeficiency virus (HIV)," "ocular syphilis," and "general paresis" as core research topics. Research focus has gradually shifted from traditional diagnostic criteria and penicillin-based treatment approaches to investigations into immune mechanisms, co-infection factors, and the identification of novel biomarkers. In recent years, the appearance of keywords such as "case report," "gene expression," and "transcriptomics" indicates a growing emphasis on precision medicine and molecular mechanisms. The increasing frequency of immune-related molecules, including CD4, CXCL13, and IL-6, suggests that the mechanisms underlying immune responses may represent a promising direction for future research breakthroughs. Conclusions: Research on neurosyphilis is transitioning from traditional clinical descriptions toward multidisciplinary precision medicine. Future efforts should focus on integrating multi-omics technologies, establishing globally unified diagnostic criteria, and enhancing international collaboration to address the public health challenges posed by this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.