Evidence map›Paper›PMID 41112258›Full record

ArticleFrontiers in immunology2025

Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development.

Luana Filippi Xavier, Ranko Gacesa, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Pablo Scharf, Fabiana da Silva Lima, Klaas Nico Faber, Hermie Harmsen, Christian Hoffmann, Sandra Helena Poliselli Farsky

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luana Filippi XavierDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Ranko GacesaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands.
Gustavo Henrique Oliveira da RochaDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Milena Fronza BroeringDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Pablo ScharfDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Fabiana da Silva LimaDepartment of Food and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Klaas Nico FaberDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands.
Hermie HarmsenDepartment of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands.
Christian HoffmannDepartment of Food and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Sandra Helena Poliselli FarskyDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammatory Bowel Diseases (IBDs) are characterized by intestinal dysbiosis and immune dysregulation. Annexin A1 (AnxA1) promotes epithelial repair and inhibits immune responses during IBD. However, AnxA1's impact on gut microbiota during IBD remains unclear. Here, we experimentally investigated the microbiota profile during colitis in wild-type (WT) and AnxA1-deficient mice (AnxA1 Methods: Colitis was induced in C57BL/6 WT and AnxA1 Results: Healthy AnxA1 Conclusion: AnxA1 is implicated in microbiota control under healthy and IBD conditions. Accordingly, the microbiota of healthy AnxA1

Indexed as

Annexin A1ColitisGastrointestinal MicrobiomeInflammatory Bowel DiseasesAdultAnimalsDextran SulfateDisease Models, AnimalDysbiosisFecesFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutAnnexin A1annexin A1, mouseANXA1 protein, humanDextran Sulfate16SANXA1Crohn’s diseaseDSS-induced colitismetagenomicsmicrobiotaulcerative colitis

Identifiers

PMID41112258
PMCPMC12531217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.