Evidence map›Paper›PMID 41112256›Full record

ArticleFrontiers in immunology2025

Transepidermal water loss increases during murine food anaphylaxis and reflects reaction severity.

Benjamin N Woerner, Joseph Abbo, Allison Wang, Melanie K Donahue, Judy Hines, Jessica O'Konek, Simon P Hogan, James R Baker, Charles F Schuler

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin N WoernerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Joseph AbboMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Allison WangMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Melanie K DonahueMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Judy HinesMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Jessica O'KonekMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Simon P HoganMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
James R BakerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.
Charles F SchulerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.

Funding

The role of epithelial barrier dysfunction in food anaphylaxisK23AI162661 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Charles F Schuler · 2022 to 2026
$972k
NIAID NIH HHS K23 AI162661NIAID NIH HHS L30 AI171988
6 · The paper itself

Abstract

Background: An increase in transepidermal water loss (TEWL) presages food anaphylaxis in allergic humans during oral food challenges. We sought to determine whether similar TEWL changes occur in mouse food anaphylaxis models. Methods: Using a Tewameter™ Nano, a mouse-compatible device, TEWL measurements were conducted on the ear, paw, and abdomen of BALB/c mice. Because of the highest measurement reproducibility, the ear was selected for use in the study. Baseline TEWL measurements under varied conditions were evaluated. Histamine injections were given to evaluate a non-IgE-mediated reaction. Two IgE-based models of food anaphylaxis were utilized: (1) passive systemic anaphylaxis (PSA) with dinitrophenyl (DNP)-IgE sensitization and DNP-albumin challenge, and (2) active systemic anaphylaxis (ASA) with ovalbumin-alum immunization followed by ovalbumin challenges. Core temperature, reaction severity score, diarrhea, and TEWL were recorded. MCPT-1 was measured as a mast cell activation correlate. Results: TEWL was reproducibly measured on the ear (17.7 g/m Conclusion: TEWL is reliably measured on the mouse ear. TEWL increased under varied reaction conditions, and the stimulus used did not alter results. TEWL offers a novel, real-time, objective, and noninvasive measure of murine food anaphylaxis that corresponds to human pathophysiology.

Indexed as

AnaphylaxisFood HypersensitivityWater Loss, InsensibleAnimalsChymasesDisease Models, AnimalFemaleImmunoglobulin EMaleMast CellsMiceMice, Inbred BALB COvalbuminSeverity of Illness IndexChymasesImmunoglobulin EMcpt1 protein, mouseOvalbuminanaphylaxisbiomarkerfood allergyfood anaphylaxistransepidermal water loss (TEWL)

Identifiers

PMID41112256
PMCPMC12528144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.