Evidence map›Paper›PMID 41112237›Full record

ArticleFrontiers in immunology2025

Bulk and single-cell transcriptome profiling reveals the dynamic immune response in granulomatous amebic encephalitis caused by

Jingjia Zhang, Xinmiao Jia, Bin Yang, Ying Ge, Wei Jiang, Yang Cong, Huanwen Wu, Huifang Liu, Jingjing Tian, Yingchun Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingjia Zhang *Department of Clinical Laboratory, State Key Laboratory of Complex Severe & Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Xinmiao Jia *Center for Bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine & Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bin Yang *Vision Medicals Center for Infection Diseases, Guangzhou, China.
Ying GeDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei JiangMedical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Yang CongDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huanwen WuDepartment of Pathology, State Key Laboratory of Complex Severe and Rare Diseases, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huifang LiuVision Medicals Center for Infection Diseases, Guangzhou, China.
Jingjing TianBiomedical Engineering Facility of National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yingchun XuDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe & Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Qiwen YangDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe & Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Balamuthia mandrillaris infection in humans is rare and usually fatal. It is well established that Methods: In this study, we conducted a cohort study of five patients with Results: Analysis of seven CSF specimens revealed a total of 5,177 DEGs as the infection progressed. The most enriched pathway among the upregulated DEGs was the "PI3K-Akt signaling pathway". Moreover, its upstream pathways, the "Toll-like receptor (TLR) signaling pathway" and "JAK/STAT signaling pathway", were also upregulated. Among these, Disscusion: Overall, our study aimed to elucidate the pathogenic mechanisms underlying

Indexed as

AmebiasisBalamuthia mandrillarisInfectious EncephalitisTranscriptomeAdultCohort StudiesFemaleGene Expression ProfilingHumansMaleMiddle AgedSignal TransductionSingle-Cell AnalysisBalamuthia mandrillarisbulk RNA-sequencingdifferentially expressed genesgranulomatous amebic encephalitissignaling pathwaysingle-cell RNA-sequencing

Identifiers

PMID41112237
PMCPMC12527871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.