Evidence map›Paper›PMID 41112226›Full record

ArticleFrontiers in cardiovascular medicine2025

Ex vivo rat heart normothermic perfusion with intermittent low flow and triiodothyronine.

Iordanis Mourouzis, Dimitris Anagnostopoulos, Vassiliki Brozou, Dimitris Kounatidis, Dimitris Giannoulis, Athanasios Lourbopoulos, Theodosios Saranteas, Constantinos Pantos

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In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Iordanis Mourouzis *Department of Pharmacology, University of Athens, Athens, Greece.
Dimitris Anagnostopoulos *Department of Pharmacology, University of Athens, Athens, Greece.
Vassiliki BrozouDepartment of Pharmacology, University of Athens, Athens, Greece.
Dimitris KounatidisDepartment of Pharmacology, University of Athens, Athens, Greece.
Dimitris GiannoulisDepartment of Pharmacology, University of Athens, Athens, Greece.
Athanasios LourbopoulosDepartment of Pharmacology, University of Athens, Athens, Greece.
Theodosios SaranteasDepartment of Anaesthesia and Cardiovascular Critical Care, School of Medicine, Attikon Hospital, University of Athens, Athens, Greece.
Constantinos PantosDepartment of Pharmacology, University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ischemia-reperfusion injury remains the main constraint of normothermic perfusion. The present study investigated the potential of therapies targeting reperfusion injury such as triiodothyronine and interventions mimicking ischemic preconditioning (PC) to optimize normothermic crystalloid perfusion. Methods: Rat hearts were perfused for 6 h with constant flow, in a Langendorff mode and Krebs-Henseleit as perfusate with glucose being the only metabolic substrate, (NP, Results: Baseline parameters were similar between groups. At the end of perfusion, no difference in LVDP was observed, LVEDP was significantly lower in PC and PC + T3 vs. NP, Conclusion: Intermittent low flow mimicking ischemic preconditioning (PC) appears to optimize crystalloid based normothermic rat heart perfusion by limiting tissue edema and diastolic and vascular dysfunction.

Indexed as

crystalloid solutionheartnormothermic perfusionpreconditioningtransplantationtriiodothyronine

Identifiers

PMID41112226
PMCPMC12533271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.