Evidence map›Paper›PMID 41112202›Full record

ArticleACS bio & med chem Au2025

Indole-2-carboxamides Optimization for Antiplasmodial Activity.

Malkeet Kumar, Anees Ahmad, Anna Caroline Campos Aguiar, Sarah El Chamy Maluf, Anwar Shamim, Mariana Ferrer, Guilherme E Souza, Marcos L Gazarini, Dhelio B Pereira, Thomas W von Geldern and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Bioactive Benzyl Terpene fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Malkeet KumarInstitute of Chemistry, University of Campinas, Barão Geraldo, PO Box 6154, Campinas, SP 13083-970, Brazil.ORCID https://orcid.org/0000-0003-1976-5890
Anees AhmadInstitute of Chemistry, University of Campinas, Barão Geraldo, PO Box 6154, Campinas, SP 13083-970, Brazil.ORCID https://orcid.org/0000-0002-5269-6199
Anna Caroline Campos AguiarSao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, 13566-590 Sao Carlos, SP, Brazil.ORCID https://orcid.org/0000-0003-0139-8279
Sarah El Chamy MalufSao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, 13566-590 Sao Carlos, SP, Brazil.ORCID https://orcid.org/0000-0002-3050-7473
Anwar ShamimInstitute of Chemistry, University of Campinas, Barão Geraldo, PO Box 6154, Campinas, SP 13083-970, Brazil.ORCID https://orcid.org/0000-0003-2849-7103
Mariana FerrerInstitute of Chemistry, University of Campinas, Barão Geraldo, PO Box 6154, Campinas, SP 13083-970, Brazil.ORCID https://orcid.org/0000-0002-6250-3047
Guilherme E SouzaSao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, 13566-590 Sao Carlos, SP, Brazil.ORCID https://orcid.org/0000-0003-3278-6688
Marcos L GazariniDepartment of Biosciences, University Federal of Sao Paulo, Ed. Ciências Biomédicas - R. Silva Jardim, 136 - Vila Mathias, Santos, SP 11015-531, Brazil.ORCID https://orcid.org/0000-0002-3882-6831
Dhelio B PereiraCentro de Pesquisa em Medicina Tropical, CEP 76812-329 Porto Velho, RO, Brazil.
Thomas W von GeldernMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland.ORCID https://orcid.org/0000-0002-0649-7885
Delphine BaudMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland.ORCID https://orcid.org/0009-0005-6745-233X
Barry JonesPharmaron U.K., West Hill Innovation Park, Hoddesdon EN11 9FH, U.K.
Susanta Kumar MondalTCG LifeSciences PVT. LTD, Block-BN, Plot-7, Sector-V, Salt Lake Electronic Complex, Kolkata 700091, India.
Paul A WillisMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland.ORCID https://orcid.org/0009-0006-0917-368X
Rafael Victorio Carvalho GuidoSao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, 13566-590 Sao Carlos, SP, Brazil.ORCID https://orcid.org/0000-0002-7187-0818
Luiz Carlos DiasInstitute of Chemistry, University of Campinas, Barão Geraldo, PO Box 6154, Campinas, SP 13083-970, Brazil.ORCID https://orcid.org/0000-0003-0628-9928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria still stands out as one of the most devastating and prevalent diseases globally, where the rise of resistance to different antimalarial drugs in different regions has posed significant obstacles to global treatment and elimination. Consequently, there is a pressing need for the development of new antimalarial agents with novel modes of action. In this study, we report the identification and optimization of new indole-2-carboxamide derivatives where structural modifications have yielded new compounds

Indexed as

antimalarialsdrug developmentindolesmalariaresistance

Identifiers

PMID41112202
PMCPMC12531871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.