Evidence map›Paper›PMID 41112200›Full record

ReviewACS bio & med chem Au2025

Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook.

Denis Fourches, Joseph Pilotte, Brian E Watts, Daniel J Saltzberg, Robert M Cicchillo

Abstract readReview
In one paragraph

Review in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Denis FourchesOerth Bio LLC, 112 South Duke Street, Durham, North Carolina 27701, United States.ORCID https://orcid.org/0000-0001-5642-8303
Joseph PilotteOerth Bio LLC, 112 South Duke Street, Durham, North Carolina 27701, United States.
Brian E WattsOerth Bio LLC, 112 South Duke Street, Durham, North Carolina 27701, United States.
Daniel J SaltzbergOerth Bio LLC, 112 South Duke Street, Durham, North Carolina 27701, United States.
Robert M CicchilloOerth Bio LLC, 112 South Duke Street, Durham, North Carolina 27701, United States.ORCID https://orcid.org/0000-0003-2830-3807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Farmers urgently need novel technologies to ensure global food security for the rapidly expanding population, yet crop protection has seen little innovation in decades. Mounting regulatory pressures, pest resistance, and environmental concerns are driving demand for novel sustainable solutions. Beyond traditional small molecule active ingredients, very few alternative modalities (

Indexed as

agriculturecrop protectionE3 ubiquitin ligasePROTACtargeted protein degradationubiquitin proteasome system

Identifiers

PMID41112200
PMCPMC12531867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.