ArticleACS bio & med chem Au2025
Allosteric Modulation of Cannabinoid Type 1 Receptor by ZCZ011: Integration of In Vitro Pharmacology and Molecular Dynamics Simulation.
Tara Chand Yadav, Lakshmipriya Indira Swaminathan, Venkat R Chirasani, Zhixing Wu, Dai Lu, Bogna M Ignatowska-Jankowska, Aron H Lichtman, Sylvia Fitting, Barkha J Yadav-Samudrala
Abstract read
In one paragraphArticle in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Tara Chand YadavDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Lakshmipriya Indira SwaminathanBiological Physics Theory Unit, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan.
Venkat R ChirasaniR. L. Juliano Structural Bioinformatics Core, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID https://orcid.org/0000-0003-1416-0438 Zhixing WuDepartment of Pharmaceutical Sciences, Texas A&M University, College Station, Texas 78363, United States.
Dai LuDepartment of Pharmaceutical Sciences, Texas A&M University, College Station, Texas 78363, United States.
Bogna M Ignatowska-JankowskaNeuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23289, United States.
Sylvia FittingDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MVCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI YAN ZHANG · 2014 to 2026
$13.8MTO AWARD THE BASE PERIOD FOR NIMH PSYCHOACTIVE DRUG SCREENING PROGRAM (PDSP). BASE POP: 08/30/2023-08/29/2024.75N95023C00021 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN · 2023 to 2025
$9.0MInvestigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis usersR01DA055523 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sylvia Fitting, Wei Jiang · 2022 to 2026
$3.5MAllosteric Targeting of Cannabinoid CB1 Receptor to Develop Non-Addictive Small Molecule AnalgesicsUG3NS128439 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LU, DAI, SELLEY, DANA E · 2022 to 2022
$2.9MCircuitry- and cell-specific exploration of CB1R positive allosteric modulators in neuroHIVR01DA064394 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sylvia Fitting · 2025 to 2026
$805kInvestigation of endocannabinoid-mediated neuroprotection in models of neuroAIDSR21DA041903 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA · 2016 to 2017
$407kNCI NIH HHS P30 CA016086NIDA NIH HHS 75N95023C00021NIDA NIH HHS P30 DA033934NIDA NIH HHS R01 DA055523NIDA NIH HHS R01 DA064394NIDA NIH HHS R21 DA041903NINDS NIH HHS UG3 NS128439
6 · The paper itselfAbstract
Over the years, the cannabinoid type 1 receptor (CB
Indexed as
CB1R positive allosteric modulatorsenantiomersmolecular dynamicsmolecular modelingneuronal culturetransactivator of transcriptionZCZ011
Identifiers
PMID41112198
PMCPMC12531869
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390