Evidence map›Paper›PMID 41112196›Full record

ArticleACS bio & med chem Au2025

Local and Global Breathing Motions Prime the Access to Buried Binding Site in an Antibiotic-Sequestering Protein.

Lawanya Natarajan, Dmitry Loginov, Alan Kadek, Petr Man, Athi N Naganathan

Abstract read
In one paragraph

Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lawanya NatarajanDepartment of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.ORCID https://orcid.org/0000-0002-9838-2080
Dmitry LoginovInstitute of MicrobiologyBioCeV, Academy of Sciences of the Czech Republic, Vestec 252 50, Czech Republic.ORCID https://orcid.org/0000-0002-4164-6145
Alan KadekInstitute of MicrobiologyBioCeV, Academy of Sciences of the Czech Republic, Vestec 252 50, Czech Republic.ORCID https://orcid.org/0000-0002-7953-5870
Petr ManInstitute of MicrobiologyBioCeV, Academy of Sciences of the Czech Republic, Vestec 252 50, Czech Republic.ORCID https://orcid.org/0000-0002-1485-2197
Athi N NaganathanDepartment of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.ORCID https://orcid.org/0000-0002-1655-7802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins frequently undergo large-scale conformational excursions in their native ensemble. Such structural transitions are particularly critical for enabling access to binding sites when they are buried in the protein interior. Here, we map the conformational landscape of AlbAS, a natural isoform of the transcription factor AlbA from the gut microbe

Indexed as

antibiotic resistanceantibiotic sequestrationdomain duplicationprotein dynamicstryptophan scanning mutagenesis

Identifiers

PMID41112196
PMCPMC12531866

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.