ArticlePCN reports : psychiatry and clinical neurosciences2025
Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline.
Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline.PCN reports : psychiatry and clinical neurosciences · 2025Article
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8 authors.
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Abstract
Aim: In individuals with cognitive decline, depressive symptoms can affect disease progression and quality of life. One factor that may be associated with depressive symptoms is phosphorylated tau (p-tau). However, the association between p-tau and depressive symptoms remains controversial. The present study examined the relationship between p-tau levels and depressive symptoms not only in terms of total scale scores of the 15-item Geriatric Depression Scale (GDS-15) but also at the item level. Methods: We conducted a cross-sectional survey of patients ( Results: Multivariable regression analysis revealed that higher levels of p-tau were significantly associated with lower GDS-15 total scores (standardized coefficient [95% confidence interval] = -0.28, [-0.48, -0.09]). Furthermore, patients with higher p-tau levels were less likely to have symptoms of GDS-15 Items 2 (Dropped interests) ( Conclusion: Our findings suggest an association between p-tau accumulation and reduced depressive symptoms. However, future longitudinal studies are required to confirm whether p-tau may be a predictive factor for depressive symptoms.
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