ArticleFrontiers in systems neuroscience2025
Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion.
Article in Frontiers in systems neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify common functional brain networks underlying heterogeneous gray matter (GM) correlates of extraversion and to characterize the neurotransmitter receptor and transporter architecture associated with these networks. Methods: A systematic literature search identified 13 voxel-based morphometry (VBM) studies reporting GM correlates of extraversion in healthy individuals ( Results: FCNM analysis revealed that reported GM correlates of extraversion converge onto specific functional networks. Spatial overlap analysis showed the highest association with the frontoparietal network (FPN) (37.32%) and the default mode network (DMN) (32.99%). Furthermore, JuSpace analysis indicated that these extraversion-linked networks exhibited significant positive spatial correlations with 5-hydroxytryptamine receptor 2A (5HT2a; Conclusion: Despite regional heterogeneity in prior VBM studies, structural GM correlates of extraversion consistently map onto the DMN and FPN. This network-based approach reconciles previous inconsistencies and highlights the importance of these large-scale networks as a plausible functional substrate underlying structural variations associated with extraversion. These findings advance a systems-level understanding of the neural basis of this core personality dimension and suggest a distinct neurochemical architecture within these networks.
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