Evidence map›Paper›PMID 41112116›Full record

ArticleNeurotrauma reports2025

Sex Dimorphism Influences Cortical Microglial Morphological and Phenotypic Marker Profile after Closed Head Mild Traumatic Brain Injury in Rats.

Pooja M Datta Roy, Jens Cuba, Kyle S Milligan, Wenqi Shi, Dongmei Wang, Michelle C LaPlaca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pooja M Datta RoyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Jens CubaFAMU College of Engineering, Florida State University, Tallahassee, Florida, USA.
Kyle S MilliganSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Wenqi ShiParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA.
Dongmei WangWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Michelle C LaPlacaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-8417-5152

Funding

T32 CTEng (Cellular and Tissue Engineering) Training ProgramT32GM145735 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Edward A. Botchwey, Andres J Garcia · 2022 to 2026
$2.3M
NIGMS NIH HHS T32 GM145735
6 · The paper itself

Abstract

Neuroinflammation is a nearly ubiquitous secondary injury process after traumatic brain injury (TBI) involving microglia. The time course of microglial functional transition between pro-inflammatory and anti-inflammatory states after mild TBI (mTBI) and the potential influence of sex in microglial response is not well-understood. To investigate interactions between sex and microglial activation states in the subacute post-mTBI period, we performed a morphological and phenotypic marker analysis on cells from male and female rats following closed head single impact (smTBI), repetitive impacts (rmTBI), or sham conditions at 24 h, 72 h, or 1 week postinjury. There was a significant increase in microglia population 24 h post-smTBI and at all time points for rmTBI in both male and female cells. Single-cell morphological analysis (24 microglia per animal) revealed no clear sex differences in microglial activation state. However, Sholl analysis demonstrated an increase in branching complexity for smTBI female cells at 24 h (area under the curve [AUC] 154 ± 2.1,

Indexed as

microglia functional statemild traumatic brain injurymorphological analysisneuroinflammationsex dimorphism

Identifiers

PMID41112116
PMCPMC12528851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.