Optimization of Spinal Cord Perfusion Pressure for Improvement of Neurological Outcome in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Gabrielle E A Hovis, Brandon Sherrod, Nitin Agarwal, Berje H Shammassian, Anthony M DiGiorgio, Ramesh Grandhi, Bryce Picton

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In one paragraph

Review in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabrielle E A HovisDepartment of Neurosurgery, University of California, Irvine, Irvine, California, USA.

Brandon SherrodDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA.

Nitin AgarwalDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Berje H ShammassianDepartment of Neurological Surgery, Louisiana State University Health, New Orleans, Louisiana, USA.

Anthony M DiGiorgioDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-5710-691X

Ramesh GrandhiDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-9000-6083

Bryce PictonDepartment of Neurosurgery, University of California, Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-3539-6167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal hemodynamic management of traumatic spinal cord injury (tSCI) is not well established. We performed a systematic review and meta-analysis of patients with acute tSCI to assess the role of lumbar cerebrospinal fluid drainage (CSFD) and to identify factors predictive of neurological improvement. Three studies involving 46 patients with acute tSCI, lumbar drain placement with CSFD, and available pre- and post-intervention American Spinal Injury Association (ASIA) Impairment Scale or International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor scores were identified. One study was analyzed separately (Cohort A) using ASIA grade because post-intervention ISNCSCI motor scores were not reported. In the remaining two studies (Cohort B), two independent meta-analyses with meta-regressions were performed to determine the mean difference in ISNCSCI motor scores by CSFD and time to decompression. Individual patient data were used for all analyses. In Cohort A, there was no significant difference in ASIA grade before lumbar CSFD and at the last follow-up (Wilcoxon signed rank test:

Indexed as

cerebrospinal fluid drainspinal cord perfusion pressurethoracoabdominal aortic aneurysmtraumatic spinal cord injury

Identifiers

PMID41112112

DOI10.1177/2689288X251377015

PMCPMC12528847

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