ReviewFrontiers in bioengineering and biotechnology2025
Mechanotransduction of autotransplants: remodeling potential of heart valves from autologous pericardial tissue.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current commercial heart valve prostheses are non-living structures, either derived from artificial materials (mechanical valves) or foreign biological materials (xeno- or homo-graft). Since the use of viable tissue with native-like properties is essential for a heart valve with self-regulation properties, autologous collagen-based tissue can be considered a promising alternative material. While the extracellular matrix of pericardial tissue offers a solid foundation, it is the interstitial cells that play a crucial role in ensuring long-term durability. This review explores the mechanotransduction capabilities of autologous tissue as a replacement material for living heart valves with regenerative potential.
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