Evidence map›Paper›PMID 41112047›Full record

ArticleiMeta2025

Characterizing the microbiome of "sterile" organs in experimental mice and evidence of translocation of bacteria from the gut to other internal organs.

Ming Xu, Shuyun Guan, Chaoran Zhong, Mingyang Ma, Li Tao, Guanghua Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A tumor-residentiScience · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ming XuShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.
Shuyun GuanShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.
Chaoran ZhongShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.
Mingyang MaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.
Li TaoShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.ORCID https://orcid.org/0000-0001-6109-3480
Guanghua HuangShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Department of Laboratory Medicine, Department of Infectious Diseases, Huashan Hospital Fudan University Shanghai China.ORCID https://orcid.org/0000-0002-4761-7548

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using culturomics and metagenomics, we demonstrate the existence of non-pathogenic microbiota in the internal organs of healthy experimental mice, challenging the traditional dogma of organ sterility. Based on the analysis of 104 commercially sourced mice (C57BL/6J, BALB/c, ICR), the study reveals that over 20% of the analyzed mice harbored a high microbial burden in the internal organs and identified a total of 463 microbial species. Several species, including

Identifiers

PMID41112047
PMCPMC12527995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.