Evidence map›Paper›PMID 41112012›Full record

ArticleWorld journal of gastroenterology2025

Clip-assisted endoscopic cyanoacrylate injection

Yang-Yang Xiong, Di-Wu Li, Tian-Yu Zhou, Han Ma, Jian-Guo Gao, Zhe Shen, Cheng-Fu Xu, Chao-Hui Yu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang-Yang XiongDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Di-Wu LiDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Tian-Yu ZhouDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Han MaDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Jian-Guo GaoDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Zhe ShenDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Cheng-Fu XuDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Chao-Hui YuDepartment of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe high rebleeding rate and severe adverse events have raised concerns regarding the safety of endoscopic cyanoacrylate as a conventional treatment for gastric variceal hemorrhage. Clip-assisted endoscopic cyanoacrylate injection (Clip-CYA) and endoscopic ultrasound-guided coil and cyanoacrylate injection (EUS-CG) are two currently used modalities. There are limited data comparing the two techniques.

aimTo compare the efficacy, safety, and procedural characteristics of Clip-CYA

methodsBetween April 2019 and August 2023, 162 patients with GVs and concomitant gastrorenal or splenorenal shunts who underwent either Clip-CYA or EUS-CG at our center were included. After 1:2 propensity score matching, 108 patients were included in the final analysis. The evaluated outcomes included the amount of cyanoacrylate, eradication of GVs, cyanoacrylate embolization, all-cause rebleeding, operating time and endoscopic therapy costs.

resultsOf the 108 patients, 72 (male, 83.3%; mean age, 56.2 ± 10.8 years) received Clip-CYA, and 36 (male, 72.2%; mean age, 59.1 ± 10.7 years) received EUS-CG. The amount of cyanoacrylate used, rates of obliteration of GVs and all-cause rebleeding were similar between the two groups (2.0 ± 1.1 mL

conclusionCompared with EUS-CG, Clip-CYA of GVs appears to be a safe procedure with shorter operating times and lower endoscopic therapy costs.

Indexed as

CyanoacrylatesEmbolization, TherapeuticEsophageal and Gastric VaricesGastrointestinal HemorrhageHemostasis, EndoscopicAdultAgedEndosonographyFemaleHumansMaleMiddle AgedOperative TimePropensity ScoreRecurrenceRetrospective StudiesCyanoacrylatesClipEndoscopic cyanoacrylateEndoscopic ultrasoundGastric varicesPortal hypertension

Identifiers

PMID41112012
PMCPMC12531803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.