ArticleFrontiers in neurology2025
Aerobic exercise improves clinical symptoms in people with Parkinson's disease and its potential mechanism.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Review
- Aerobic Exercise Improves Motor Performance by Reducing Total ERK Expression and Hyperexcitability of Striatal D2-MSNs in MPTP-Induced Parkinsonian Mice.Molecular neurobiology · 2026Article
- The exercise-microbiota-queuine-tRNA axis in Parkinson's disease: evidence, uncertainties, and experimental priorities.Frontiers in neuroscience · 2026Review
- Improved cognitive flexibility after high-intensity interval training (HIIT) in individuals with Parkinson's disease: a pilot randomized controlled trial.Frontiers in rehabilitation sciences · 2026Article
- Exercise suppresses apoptosis for alleviating Parkinson's disease: effects on pathophysiological molecular pathways.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increasing body of research has identified a correlation between dysbiosis of the intestinal microbiota and the onset and progression of Parkinson's disease. Furthermore, aerobic exercise has been shown to positively influence the regulation of intestinal microbiota. This study aims to examine the effects of aerobic exercise on the clinical symptoms of people with Parkinson's disease and the underlying mechanisms. Methods: Twenty-six participants engaged in 8 weeks moderate-intensity aerobic exercise. The outcomes include the World Movement Disorder Society Unified Parkinson's Disease Comprehensive Rating Scale part III and so on. Concurrently, fecal and blood samples were collected from the subjects. Results: After aerobic exercise, the MDS-UPDRS part III score decreased. There was a statistically significant increase in the relative abundance of Conclusion: Aerobic exercise has been shown to enhance both motor and non-motor functions in people with Parkinson's disease. The underlying mechanisms may involve the modulation of intestinal flora composition and diversity, bile acid metabolism, and inflammatory cytokine levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.