ArticleJournal of the National Cancer Center2025
BTEX chrono-metabolism and leukemogenic effects of night shift work in workers of gasoline stations: the EXPOSOWORK prospective panel study in Bulgaria.
Article in Journal of the National Cancer Center, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Εndogenous metabolomic responses in circadian disrupted night shift working populations: a scoping review.Journal of the National Cancer Center · 2026Review
- Biological time and occupational leukemogenesis: the circadian rhythm as a cofactor in benzene toxicity.Journal of the National Cancer Center · 2026Article
- Work at night, sleep loss, fatigue, and cancer: exposure, mechanisms, and epidemiological evidence.Journal of the National Cancer Center · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Exposures to benzene, toluene, ethylbenzene and xylenes (BTEX) have been associated with impairment of the hematopoietic system, often leading to leukemogenesis. A prospective panel study: i) characterized the effect of night shift work (NSW) (12-hr night shift vs. 12-hr day shift) on urinary BTEX and metabolites in gasoline station workers in Plovdiv, Bulgaria, ii) evaluated the NSW effect on chrono-based BTEX genotoxic effects (as measured by 8-OHdG, a nonspecific biomarker of genotoxicity) including the influence of the downstream urinary metabolome. Methods: During a week's working period, workers (n=71) followed both day shift and night shift work schedules (12-h long each shift) collecting four urine samples per worker (pre and end of shift). Airborne BTEX exposures were evaluated over 12-h shift periods using wearable passive samplers. Urinary BTEX and the metabolome were measured using mass spectrometry. 8-OHdG was measured using an ELISA immunoassay. Associations were examined using mixed-effect regression models and corrected for false-discovery rates of 0.05. Results: Median personal airborne benzene levels were 3.05 (IQR: 2.89), and 2.92 (IQR: 1.86) μg/m Conclusion: Larger NSW studies with longer and more frequent follow-up times are warranted to better delineate the possible influence of NSW chrono-modulated working activities in leukemogenic processes.
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