ArticleCureus2025
Subacute Combined Degeneration Due to Inhalant Use: Not a Laughing Matter.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrous oxide, known as "laughing gas," is a substance that can be used to induce analgesia and euphoria. It is easily accessible in certain household products, such as aerosol canisters used for food products. However, chronic use of nitrous oxide can inhibit cobalamin (vitamin B12), causing severe deficiencies that result in psychiatric, hematologic, and neurological toxicities, including subacute combined degeneration of the spinal cord. We present a case of a young adult male who developed progressive, ascending bilateral paresthesias and gait disturbances, ultimately attributed to nitrous oxide use. This case highlights the neurotoxic effects and symptoms associated with recreational nitrous oxide use, as well as the patient's treatment and subsequent clinical recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.