Evidence map›Paper›PMID 41111700›Full record

ArticleCureus2025

A Comparative Study of Carotid Ultrasound Findings in Patients With and Without Familial Hypercholesterolemia.

Rina Nakajima, Hiroki Yamazaki, Kayoko Kozuma, Takashi Suzuki, Kenji Uno, Koji Morita, Toshio Ishikawa, Satoshi Miyata, Tamio Teramoto, Kazuhisa Tsukamoto

Abstract read
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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rina NakajimaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Hiroki YamazakiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Kayoko KozumaTeikyo Academic Research Center, Teikyo University, Tokyo, JPN.
Takashi SuzukiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Kenji UnoDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Koji MoritaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Toshio IshikawaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.
Satoshi MiyataTeikyo Academic Research Center, Teikyo University, Tokyo, JPN.
Tamio TeramotoTeikyo Academic Research Center, Teikyo University, Tokyo, JPN.
Kazuhisa TsukamotoDivision of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeFamilial hypercholesterolemia (FH) is a genetic disorder that can lead to coronary artery disease and heart valve disease at a young age. Carotid ultrasound is a relatively simple examination for evaluating atherosclerosis. This study aimed to clarify the differences in carotid ultrasound findings between FH and non-FH patients and to identify the characteristics of atherosclerosis in FH. SUBJECTS AND

methodsPatients with FH or non-FH who underwent carotid ultrasound at a dyslipidemia clinic were enrolled. Background information and clinical laboratory values were extracted at the time of the initial ultrasound examination. Background factors were matched, and carotid ultrasound findings (plaque score (PS) and intima-media thickness (IMT)) were compared between the two groups.

resultsThe FH group exhibited significantly higher levels of PS and IMT than the non-FH group. In those under 50 years of age, no significant differences in PS or IMT were observed between the FH and non-FH groups. On the other hand, in those aged 50 years or over, the FH group exhibited significantly higher levels of PS and IMT than the non-FH group. There were no significant differences in the changes and change rates in PS and IMT over time between the two groups.

conclusionThe importance of early diagnosis and adequate treatment of FH was suggested in FH management.

Indexed as

atherosclerosiscarotid ultrasoundfamilial hypercholesterolemiaintima-media thicknessplaque score

Identifiers

PMID41111700
PMCPMC12529430

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