Evidence map›Paper›PMID 41111654›Full record

ArticleCureus2025

Long-Term Oncological Outcomes Following Anastomotic Leakage After Colorectal Cancer Surgery: A Retrospective Monocenter Trial.

Mario Kaufmann, Julia Hardt, Christopher Bozinov, Lothar Pilz, Steffen Seyfried, Christoph Reissfelder, Georgi Vassilev, Georgi Kalev

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mario KaufmannDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Julia HardtDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Christopher BozinovDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Lothar PilzDepartment of Biostatistics and Epidemiology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Steffen SeyfriedDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Christoph ReissfelderDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Georgi VassilevDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.
Georgi KalevDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, DEU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesColorectal cancer (CRC) ranks among the most common cancers worldwide. One of the most severe postoperative complications is an anastomotic leakage (AL). The aim of this study was to investigate the impact of AL on the long-term oncologic outcome.

methodsAll patients who underwent curative surgery for CRC at the Department of Surgery at the University Hospital in Mannheim between January 2011 and June 2016 were retrospectively analyzed. The primary endpoint was the overall survival (OS).

resultsBetween January 2011 and June 2016, a total of 504 patients were included in the study. The median follow-up was 42 months. We found an AL incidence of 11.1% (n = 56) with the following risk factors: age ≤ 65 (p = 0.03) and location of the tumor in the rectum, especially mid-rectum (p = 0.012). Patients with AL were less likely to have adjuvant chemotherapy (p = 0.002). AL had no significant impact on the OS (p = 0.09). Patients with AL had a significantly higher 90-day mortality (p = 0.002), whereas there was no significant impact on local or distant recurrence.

conclusionIn our cohort, age ≤ 65 and a cancer location in the mid-rectum were risk factors for AL. However, our results did not demonstrate a significant influence of AL on the oncological long-term outcome.

Indexed as

anastomotic leakagecolorectal cancercolorectal cancer surgerylong-term outcomeoverall survival (os)

Identifiers

PMID41111654
PMCPMC12532467

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