Evidence map›Paper›PMID 41111648›Full record

ArticleCureus2025

A Comparison of Whole-Brain Dose During Stereotactic Radiosurgery for Multiple Metastases Across Technology Platforms.

Neelan J Marianayagam, Ziyi Wang, Alonso N Gutierrez, D Jay Wieczorek, Ian Paddick, Yusuke S Hori, David J Park, Steven D Chang, Stephanie Key, Georg A Weidlich and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Neelan J MarianayagamNeurosurgery, Stanford University, Stanford, USA.
Ziyi WangRadiation Oncology, Stanford Health Care Cancer Center, Palo Alto, USA.
Alonso N GutierrezRadiation Oncology, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.
D Jay WieczorekRadiation Oncology, Miami Cancer Institute, Miami, USA.
Ian PaddickMedical Physics, Medical Physics Limited, London, GBR.
Yusuke S HoriNeurosurgery, Stanford University School of Medicine, Stanford, USA.
David J ParkNeurosurgery, Stanford University School of Medicine, Stanford, USA.
Steven D ChangNeurosurgery, Stanford University School of Medicine, Stanford, USA.
Stephanie KeySales and Marketing, ZAP Surgical Systems, Inc., San Carlos, USA.
Georg A WeidlichMedical Physics, ZAP Surgical Systems, Inc., San Carlos, USA.
John AdlerRadiation Oncology, ZAP Surgical Systems, Inc., San Carlos, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic radiosurgery (SRS) is now the gold standard radiation technique for the treatment of multiple brain metastases. By virtue of its targeting accuracy, SRS, relative to whole-brain radiotherapy (WBRT), maximizes both the likelihood of tumor ablation while minimizing irradiation (injury) of the uninvolved brain. The extent to which the latter objective is accomplished varies among radiosurgery platforms. In this study, we used a standardized imaging dataset taken from a patient with 10 random brain metastases to calculate the radiation dose delivered to the uninvolved normal brain across a range of modern SRS delivery platforms. This analysis reveals that irradiation of the uninvolved brain is considerably less on dedicated cranial SRS devices compared to multi-purpose C-arm and full-body robotic systems. Given the growing recognition of lower-dose radiation's deleterious effects, these findings may have relevance to patient and technology selection.

Indexed as

gamma knife (gk) radiosurgerygyroscopic radiosurgerylinac-based radiosurgerystereotactic radiosurgerytreatment of brain metastaseswhole brain radiation dose

Identifiers

PMID41111648
PMCPMC12530002

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.