ReviewEuropean cardiology2025
Meta-analysis and Meta-regression for Uncertain Areas and the Estimation of Possible Benefit of Future Therapies.
Review in European cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic implications of PD-L1 expression in gastric cancer: systematic review and meta-analysis of studies published between 2018 and 2025.BMC cancer · 2026Pooled it
- Bleeding benefit, ischemic safety, and stent thrombosis risk of early aspirin discontinuation after percutaneous coronary intervention: A time-based meta-regression analysis.JRSM cardiovascular diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meta-analysis and meta-regression are feasible and reliable statistical tools to assess the joint effect of divergent studies and studies that were underpowered or in uncertain areas. Meta-analysis should be performed accurately and have a clear objective. Conclusions of meta-analyses should not rely on small numbers of events and should not tell what is already known or obscure what should be remembered; similarly, those that rely on indirect comparison should be cautiously interpreted. New aspects of meta-analyses include analysis of subgroups, multivariate adjustment, assessment of bias or network meta-analyses. Meta-regression can elucidate the effect on variables predicted according to the results of previously available studies and can be adjusted for one or more explanatory variables that might influence the size of intervention effect. This has also been used for the estimation of the effect of novel therapies. This review summarises current knowledge related to metaanalysis and meta-regression with published examples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.