ArticleFrontiers in pharmacology2025
Exploring the antioxidant potential of prolactin.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Prolactin (PRL) is primarily recognized for its role in lactation, yet its antioxidant function remains incompletely elucidated. The purpose of the present study was to examine the antioxidative role of prolactin. Methods: Seventy female volunteers were equally divided into hyperprolactinemia and control groups in this case-control study. Total antioxidant status (TAS), total oxidant status (TOS), native thiol (NT), total thiol (TT), prolactin, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) analyses were performed using the serum samples with the relevant kits based on the colorimetric or spectrophotometric methods. In addition, oxidative stress index (OSI), disulfide (DS), and the percent ratios of disulfide/native thiol (DS/NT), disulfide/total thiol (DS/TT), and native thiol/total thiol (NT/TT) were also determined. Results: TAS, NT, and TT concentrations and NT/TT percent ratio were found to be higher in patients than in the control group ( Discussion/Conclusion: Hyperprolactinemia elevated total antioxidant and thiol levels while suppressing total oxidants, oxidative stress, and disulfide/thiol ratios. These findings indicate that prolactin plays a pivotal role in maintaining thiol-disulfide homeostasis and oxidative balance, functioning as a crucial endogenous antioxidant hormone. Moreover, the elevated prolactin levels during gestation and lactation may reflect its essential contribution to maternal-infant antioxidant defense, thereby supporting optimal fetal development.
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