ArticleFrontiers in pharmacology2025
Genetic and serum biomarkers of NSAID hypersensitivity reactions.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypersensitivity reactions (HRs) to non-steroidal anti-inflammatory drugs (NSAIDs) constitute a significant clinical concern due to their frequency and possible severity. These reactions may involve specific immunological pathways, including activation of the high-affinity IgE receptor, or non-immunological mechanisms that result in similar clinical manifestations. Additionally, vitamin D plays an important role in the regulation of the immune response and therefore may be relevant to the development or progression of HRs to NSAIDs. Methods: To identify new single nucleotide variants (SNVs) associated with HRs, we analyzed the exonic regions and the 3'UTR of sixteen genes related to the vitamin D pathway and the high-affinity IgE receptor, namely, Results: We identified 216 variants located in the exonic and 3'regions of these genes, 186 of which were novel. Multinomial analyses identified associations between patients with single NSAID induced urticaria/angioedema or anaphylaxis (SNIUAA) and SNVs in genes related to vitamin D ( Conclusion: Our study highlights a significant association between SNVs in genes related to the vitamin D pathway, retinoid receptors and the high-affinity IgE receptor with the risk of NSAIDs HRs. Additionally, the correlation between IgE levels and clinical phenotypes suggests a potential role for this biomarker in the pathophysiology and stratification of these reactions.
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