Evidence map›Paper›PMID 41111480›Full record

ArticleHistology and histopathology2026

MPO-Mediated oxidative stress regulates lung tissue damage in T-COPD through activation of the NLRP3 inflammasome.

Wen Li, Kaican Zong, E Jiang, Chunyan Luo, Hengyi Chen

Abstract read
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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wen LiDepartment of Respiratory and Critical Care Medicine, The Seventh People's Hospital of Chongqing, Affiliated Central Hospital of Chongqing University of Technology, Chongqing, China.
Kaican ZongDepartment of Respiratory and Critical Care Medicine, The Seventh People's Hospital of Chongqing, Affiliated Central Hospital of Chongqing University of Technology, Chongqing, China.
E JiangDepartment of Respiratory and Critical Care Medicine, The Seventh People's Hospital of Chongqing, Affiliated Central Hospital of Chongqing University of Technology, Chongqing, China.
Chunyan LuoDepartment of Respiratory and Critical Care Medicine, The Seventh People's Hospital of Chongqing, Affiliated Central Hospital of Chongqing University of Technology, Chongqing, China.
Hengyi ChenDepartment of Respiratory and Critical Care Medicine, The Seventh People's Hospital of Chongqing, Affiliated Central Hospital of Chongqing University of Technology, Chongqing, China. hilliry@126.com.

Funding

Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) 2024QNXM033
6 · The paper itself

Abstract

purposeThis study aimed to investigate the role of MPO in regulating the NLRP3 signaling pathway and its impact on lung injury in a

methodsT-COPD was induced in mice by stimulating with

resultsHistological analysis of the

conclusionOur results suggest that MPO plays a critical role in regulating the NLRP3 signaling pathway, contributing to lung injury in the T-COPD model. Inhibition of MPO with MPO-IN-5 effectively alleviates inflammation, reduces oxidative stress, and suppresses NLRP3 pathway activation, highlighting its potential as a therapeutic target for T-COPD.

Indexed as

InflammasomesLungNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressPeroxidasePulmonary Disease, Chronic ObstructiveAnimalsCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLMycobacterium tuberculosisSignal TransductionCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePeroxidase

Identifiers

PMID41111480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.