Evidence map›Paper›PMID 41111467›Full record

ArticleCurrent organic synthesis2025

Innovative Green Synthesis and Multifunctional Applications of Pyrimidopyrimidine Derivatives.

Ruchi Bharti, Ankita Thakral, Ajay Thakur, Bhaktisudha Sahu, Monika Verma, Renu Sharma, Parul Narwal, Anshi Gupta, Vipasha Sharma, Ravi Bansal

Abstract read
PubMed Publisher
In one paragraph

Article in Current organic synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effects and Mechanisms of Long-TermFoods (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruchi BhartiDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.ORCID 0000-0001-9529-9233
Ankita ThakralDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.
Ajay ThakurDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.
Bhaktisudha SahuDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.
Monika VermaDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.
Renu SharmaDepartment of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.
Parul NarwalDepartment of Biotechnology, UIS, Chandigarh University, Mohali, Punjab, India.
Anshi GuptaDepartment of Biotechnology, UIS, Chandigarh University, Mohali, Punjab, India.
Vipasha SharmaDepartment of Biotechnology, UIS, Chandigarh University, Mohali, Punjab, India.
Ravi BansalSchool of Chemical Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis research introduces an eco-friendly, one-pot multicomponent synthesis of pyrimidopyrimidines (4a-4i) and amino-1,3-dimethylpyrimidines (5a-5d) in an aqueous medium, utilizing citric acid as a catalyst.

aimsThe study aimed to establish a sustainable method for synthesizing these heterocyclic compounds while evaluating their biological activities.

methodsStructural characterization of the synthesized compounds was conducted through elemental analysis, IR, and NMR spectroscopy. The DPPH, TAC, and ABTS methods assessed the antioxidant properties, revealing their significant potential as bioactive agents. Compound 4i demonstrated the highest antioxidant activity with a DPPH inhibition of 99.13%, while compound 5b exhibited the highest ABTS activity of 100%. Advanced computational analysis using Density Functional Theory (DFT) at the B3LYP/6-311+G(d,p) level provided insights into the compounds' molecular structures, reactivity, and electronic properties.

resultsKey findings include the energy band gap analysis, which revealed compound 4c as the most stable (energy gap 5.102 eV) and compound 4i as the most reactive (energy gap 3.51 eV). These theoretical calculations, aligned with experimental NMR data, validated the molecular structures and confirmed the accuracy of theoretical predictions. Additionally, antibacterial and antifungal assays identified compound 4i as the most effective against Grampositive and Gram-negative bacteria and Candida albicans.

conclusionThis work highlights the potential of these derivatives as promising candidates for therapeutic applications and contributes to advancing environmentally benign synthetic methodologies.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAntioxidantsGreen Chemistry TechnologyPyrimidinesDensity Functional TheoryMicrobial Sensitivity TestsMolecular StructurePicratesAnti-Bacterial AgentsAntifungal AgentsAntioxidantsPicratesPyrimidinesantibacterial activityantifungal studyantioxidant assays.density functional theoryGreen synthesispyrmidopyrimidine derivatives

Identifiers

PMID41111467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.