ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.Chembiochem : a European journal of chemical biology · 2026Review
- Self-Assembled Berberine-Sinapic Acid Nanomedicine for Synergistic Chemotherapy.Molecules (Basel, Switzerland) · 2026Article
- A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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9 authors.
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Abstract
Conventional chemical or biological synthetic methods often encounter challenges in conveniently preparing chiral natural and unnatural products with the same skeleton at a scalable level, due to their complexity with numerous chiral centers or uncharacterized enzymes. Herein, a simplified modular chemoenzymatic platform is designed featuring a streamlined four-enzyme cascade coupled with a chemical module that involves one or two chemical steps. This platform enables the divergent synthesis of structurally diverse natural and unnatural benzylisoquinoline alkaloids (BIAs), including 1-benzylisoquinoline, protoberberine, morphinan, and aporphine alkaloids. Moreover, the enantioselectivity of the chiral BIAs is up to 99% ee. The titer of papaverine reaches an impressive 2.83 g L
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