Evidence map›Paper›PMID 41111460›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Morphine Tolerance Gated through EZH2-Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice.

Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun-Yi Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Li WanJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Mengyao ZhangJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Haiyue GuoJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Yan XuDepartment of Pain, the first people 's hospital of Changzhou, Soochow University, Changzhou, Jiangsu, 213000, China.
Chenjie XuDepartment of Anesthesiology and Pain, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
Fan HuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Yinbing PanDepartment of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Xian WangDepartment of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu, 210004, China.
Wentao LiuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Chun-Yi JiangJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.ORCID https://orcid.org/0000-0002-4547-0677

Funding

Jiangsu Provincial Key Research and Development Program BE2021615Key R&D Program (Social Development) Project of Jiangsu Province BE2019732Major Project of "Science and Technology Innovation Fund" of Nanjing Medical University 2017NJMUCX004Nanjing Medical Science and Technology Development Fund ZKX23040Nanjing Special Fund for Health Science and Technology Development YKK19170National Natural Science Foundation of China 81870870National Natural Science Foundation of China 81971047National Natural Science Foundation of China 82271252
6 · The paper itself

Abstract

A major unresolved issue in managing severe pain is tolerance caused by repeated treatment of opioid analgesics. Here, it is demonstrated that tolerance-inducing treatment with morphine results in the persistent downregulation of transient receptor potential canonical 5 (TRPC5), impairing the Ca

Indexed as

Drug ToleranceEnhancer of Zeste Homolog 2 ProteinGABAergic NeuronsInterneuronsMorphineTRPC Cation ChannelsAnalgesics, OpioidAnimalsMaleMiceMice, Inbred C57BLAnalgesics, OpioidEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseMorphineTrpc5 protein, mouseTRPC Cation ChannelsEZH2GABAergic interneuronsMorphine toleranceTRPC5

Identifiers

PMID41111460
PMCPMC12766986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.