Evidence map›Paper›PMID 41111440›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents.

Shudi Pan, Zhenjiang Li, Juan Pablo Lewinger, Jesse A Goodrich, Hongxu Wang, Sarah Rock, Carmen Chen, Todd M Jenkins, Stephanie Sisley, Stephen R Daniels and 13 more

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In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shudi PanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0003-2583-2607
Zhenjiang LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-4806-6231
Juan Pablo LewingerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-0692-2570
Jesse A GoodrichDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0001-6615-0472
Hongxu WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-4980-219X
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-9851-2594
Carmen ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-6022-9646
Todd M JenkinsDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH (T.M.J.).
Stephanie SisleyDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (S.S.).
Stephen R DanielsDepartment of Pediatrics, School of Medicine, University of Colorado, Aurora, CO (S.R.D.).ORCID 0000-0001-5520-6952
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA (D.I.W.).ORCID 0000-0003-2912-398X
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0001-5541-5447
Erika GarciaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0001-6050-7880
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, CA (M.A.L.M.).ORCID 0000-0002-5720-5862
Tanya L AldereteDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (T.L.A.).ORCID 0000-0002-7751-9543
Zhuanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-6424-6697
Frank D GillilandDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-9033-7269
Thomas H IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, IL (T.H.I., J.R.R.).ORCID 0000-0001-7782-1112
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-2941-7833
Justin R RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, IL (T.H.I., J.R.R.).ORCID 0000-0002-7506-9497
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA (S.P., Z.L., J.P.L., J.A.G., H.W., S.R., C.C., M.T.A., E.G., R.C., S.P.E., Z.C., F.D.G., D.V.C., L.C.).ORCID 0000-0002-3319-2438

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4M
Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)P42ES036506 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAIA LIDA CHATZI · 2025 to 2026
$8.2M
Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicalsR01ES030364 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2024
$3.2M
Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1M
Longitudinal integration of environmental exposures, omics, and childhood NAFLD (LEON) StudyU01HG013288 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AUNG, TUN (MAX) M, CHATZI, VAIA LIDA · 2023 to 2025
$2.4M
Hepatotoxic effects of perfluoroalkyl substances: a new epidemiological approach for studying environmental fatty liver diseaseR01ES030691 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2022
$1.9M
NHGRI NIH HHS U01 HG013288NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1 DK095710NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P42 ES036506NIEHS NIH HHS R01 ES029944NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01 ES030691
6 · The paper itself

Abstract

backgroundEmerging omics approaches, including metabolomics and proteomics, can be integrated into obesity treatment for better blood pressure management. We tested whether preoperative metabolomic and proteomic profiles predict long-term elevated blood pressure (EBP) changes better than known risk factors in adolescents undergoing bariatric surgery.

methodsWe included 108 participants from the Teen-LABS (Teen-Longitudinal Assessment of Bariatric Surgery). Plasma untargeted metabolomics (via liquid chromatography with high-resolution mass spectrometry) and Olink proteomics were assessed pre surgery. An elastic net model with stability selection was used to identify features predictive of EBP reductions 5 years post surgery. Models including identified metabolites, proteins, and known risk factors (age, sex, race, clinical sites, parents' education level, body mass index, systolic blood pressure, and diastolic blood pressure at baseline) were compared with known-risk-factors-only models. For biological relevance, the consistency of association directions was examined in a multiethnic non-interventional adolescent cohort (n=79).

resultsMetabolite-based models and protein-based models with known risk factors each outperformed known-risk- factors-only models in predicting EBP reductions (

conclusionsThis is the first study identifying potential preoperative biomarkers for EBP reductions in adolescents following bariatric surgery. Integrating metabolomics and proteomics with known risk factors substantially improved predictive models compared with known-risk-factors-only models. Larger and more diverse cohorts are needed to confirm these findings and whether identified features are associated with other blood pressure treatments.

Indexed as

Bariatric SurgeryBlood PressureHypertensionMetabolomicsPediatric ObesityProteomicsAdolescentBiomarkersFemaleHumansLongitudinal StudiesMaleRisk FactorsBiomarkersadolescentbariatric surgerybiomarkershypertensionmetabolomicsobesityproteomics

Identifiers

PMID41111440
PMCPMC12764392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.