ArticleJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Carbofuran Exposure Alters Autophagy Flux in Human Cornea
Article in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeCarbofuran (CF) exposure causes ocular injury, but the underlying mechanism remains elusive. This study examined CF's cytotoxicity and autophagy modulation in human cornea using
methodsHealthy human cadaver corneas were used for generating primary corneal stromal fibroblasts (hCSFs) and
resultsCarbofuran reduced hCSFs' viability in a dose-dependent manner. Cytotoxicity was not detected at ≤10 µM concentrations, whereas a significant progressive cytotoxicity was observed at concentrations ≥10 µM (
conclusionCarbofuran cytotoxicity to human cornea encompasses autophagy modifications
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