ArticleRenal failure2025
Liquid-liquid phase separation-related genes in the immune microenvironment and diagnosis of focal segmental glomerulosclerosis and minimal change disease.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) are major causes of primary nephrotic syndrome. However, the mechanisms of liquid-liquid phase separation (LLPS)-related genes in the development of FSGS and MCD remain unclear. We retrieved the Gene Expression Omnibus (GEO) database for the expression profiles of FSGS and MCD and identified the differentially expressed genes (DEGs) related to LLPS. Algorithms including Vector Machine-Recursive Feature Elimination (SVM-RFE) and Random Forest (RF) were adopted to identify the candidate genes. Functional enrichment analysis, nomogram, immune infiltration analysis, the receiver operating characteristic
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