ArticleCell & bioscience2025
CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla.
Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Central Sympathetic Nerve Activation-Mediated Hypertension: Target Mechanisms and Multimodal Interventions-From Basic Research to Clinical Translation.International journal of molecular sciences · 2026Review
- Emerging roles of astrocytes in autonomic control of blood pressure and hypertension.American journal of physiology. Cell physiology · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe rostral ventrolateral medulla (RVLM) is a critical vasomotor center that plays a pivotal role in the pathogenesis of hypertension. However, the involvement of circular RNAs (circRNAs) in this nucleus in blood pressure (BP) regulation remains incompletely understood.
methodsIn this study, we investigated functional circRNAs in the RVLM associated with hypertension and elucidated their underlying mechanisms using multiple experimental approaches, including RNA sequencing (RNA-seq), primary cell culture, and intra-RVLM microinjection.
resultsOur results revealed a significantly elevated level of the highly conserved circCdh7 in the RVLM of spontaneously hypertensive rats (SHRs). Downregulation of circCdh7 in the RVLM reduced neuronal excitability, sympathetic outflow, and BP in SHRs. Mechanistically, circCdh7 functioned as a sponge for miR-346. miR-346 knockdown largely abolished the inhibitory effects of circCdh7 suppression on RVLM astrogliosis and neuroinflammation. Furthermore, miR-346 was found to target Osmr. Overexpression of miR-346 attenuated RVLM astrogliosis and neuroinflammation, but these beneficial effects were abolished by Osmr overexpression.
conclusionsCollectively, our findings demonstrate that elevated circCdh7 expression in the RVLM drives hypertension progression, with the circCdh7/miR-346/Osmr axis serving as a key regulatory mechanism. Targeting circCdh7 may represent a promising therapeutic strategy for hypertension.
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