SynthesisNeurosurgical review2025
Efficacy of neurosurgical intervention in syrinx resolution in patients presenting with Chiari malformation type I and syringomyelia: a systematic review and radiological meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Neurosurgical techniques have been used to treat Chiari Malformation type 1 (CM1). However, there remains some uncertainty regarding which neurosurgical procedure is most efficacious in treating patients with CMI and syringomyelia. Our study aims to compare the efficacy of available neurosurgical techniques in resolving syrinx for patients with CM1 and syringomyelia. Included studies must report both pre-and post-operative syrinx measurements, discuss the use of nurosurgery, and involve patients with CM1 and syringomyelia. Studies with less than 5 patients were excluded. Databases used to identify studies included PubMed, Scopus, Cochrane Library, Web of Science, and Ovid. The Newcastle-Ottawa Scale, Joanna Briggs Institute checklist, and the Risk of Bias 2 analysis tools assesed the risk of bias in the study. A meta-analysis was conducted using a random-effects model, and forest plots illustrated the results. A total of 20 studies involving 3,063 patients with CM1 and syringomyelia were included in the study. Posterior fossa decompression with duraplasty (PFDD) demonstrated significant syrinx reduction: syrinx width (SW) reduced by a mean difference (MD) of 2.46 mm (95% CI: 2.16-2.76), syrinx length by 1.68 vertebral segments (95% CI: 1.44-1.92), and syrinx-to-cord ratio by 0.21( 95% CI: 0.15 to 0.26). Posterior fossa decompression with tonsillar reduction (PFDTR) had significantly reduced SW (MD: 2.85 mm, 95% CI: 1.99-3.71). It was superior to PFDD in the syrinx-to-cord ratio (MD: 0.04, 95% confidence interval (CI) of 0.01 to 0.08). Fourth ventricular stents (FVS) and syringo-subarachnoid shunts (SSS) were other reported techniques, but there were insufficient studies for formal analysis. PFDD and PFDRT are both efficacious in reducing syrinx size in patients with CM1 and syringomyelia. PDRT displayed modest superiority in syrinx resolution, and the clinical significance of this is limited. More studies are needed to determine the efficacy of FVS and SSS.
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