Evidence map›Paper›PMID 41111081›Full record

ArticleChinese journal of integrative medicine2026

Dendrobium officinale Polysaccharides Protected against CCl

Qin Fan, Liu-Qing Yang, Xian-Xian Tian, Ying Xu, Ji-Na Luo, Xu-Wei Liu, Lan-Hua Chen, Sen Kou, Yu-Ming Shi, Ya-Jie Bai and 4 more

Abstract read
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Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qin FanDepartment of Anatomy, School of Basic Medicine, Dali University, Dali, Yunnan Province, 671000, China.
Liu-Qing YangDepartment of Anatomy, School of Basic Medicine, Dali University, Dali, Yunnan Province, 671000, China.
Xian-Xian TianDepartment of Anatomy, School of Basic Medicine, Dali University, Dali, Yunnan Province, 671000, China.
Ying XuDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Ji-Na LuoDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Xu-Wei LiuDepartment of Anatomy, School of Basic Medicine, Dali University, Dali, Yunnan Province, 671000, China.
Lan-Hua ChenDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Sen KouDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Yu-Ming ShiDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Ya-Jie BaiDepartment of Anatomy, School of Basic Medicine, Dali University, Dali, Yunnan Province, 671000, China.
Qing-Fang JiDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Yuan LongDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Jia-Mao ChengDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China.
Hai-Yan ChenDepartment of Ultrasound, the First Affiliated Hospital of Dali University, Dali, Yunan Province, 671000, China. 316573230@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the potential anti-liver fibrosis (LF) effects of Dendrobium officinale polysaccharides (DOPs) and to further explore the involvement of the antioxidant and anti-inflammatory mechanisms of the transforming growth factor-beta 1 (TGF-β1) and Wnt signaling pathways.

methodsSeventy male Sprague-Dawley rats were assigned to 5 groups in a randomized block design: control, model, colchicine (COL, 0.1 mg/kg), low-dose DOP (LDD, 0.05 g/kg), and high-dose DOP (HDD, 0.1 g/kg) groups (n=14 per group). LF rat model was induced via subcutaneous injection of carbon tetrachloride (CCl

resultsCompared with the model group, HDD dramatically improved liver appearance and index, and alleviated extensive hepatocyte degeneration, interstitial fibrous proliferation, and pseudolobuli formation (P<0.01). Moreover, HDD downregulated mRNA and protein levels of α-smooth muscle actin, type I collagen, and type III collagen in the liver tissue of rats, while maintaining the MMP-1/TIMP-1 ratio by upregulating MMP-1 and downregulating TIMP-1 (P<0.05 or P<0.01). The ARFI and CEUS examination results also confirmed that HDD had significant anti-LF effects. HDD inhibited activation of the TGF-β and Wnt/β-catenin signaling pathways by reducing mRNA and protein levels of TGF-β1, Wnt-1 and β-catenin, while increasing the expression of dickkopf-1 (P<0.05 or P<0.01).

conclusionsDOPs achieved an anti-LF effect by inhibiting TGF-β1 and Wnt/β-catenin signaling. ARFI and CEUS can be used to evaluate the liver stiffness, microcirculation disorders, and drug efficacy in LF and cirrhosis.

Indexed as

DendrobiumLiver CirrhosisOxidative StressPolysaccharidesProtective AgentsTransforming Growth Factor beta1Wnt Signaling PathwayAnimalsCarbon TetrachlorideLiverMaleRatsRats, Sprague-DawleyTissue Inhibitor of Metalloproteinase-1Carbon TetrachloridePolysaccharidesProtective AgentsTissue Inhibitor of Metalloproteinase-1Transforming Growth Factor beta1Chinese medicineDendrobium officinale polysaccharidesliver fibrosistransforming growth factor betaultrasound assessmentWnt/β-catenin

Identifiers

PMID41111081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.