Evidence map›Paper›PMID 41110851›Full record

ArticleThe Journal of physiology2026

Fentanyl blockade of K

Aguan D Wei, Nicholas J Burgraff, Luiz M Oliveira, Thiago S Moreira, Jan-Marino Ramirez

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Roles of peripheral and central µAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Aguan D WeiNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Nicholas J BurgraffNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Luiz M OliveiraNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Thiago S MoreiraNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Jan-Marino RamirezNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid OverdoseR00HL168211 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Nicholas J Burgraff · 2025 to 2026
$498k
Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid OverdoseK99HL168211 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BURGRAFF, NICHOLAS J · 2024 to 2025
$243k
Brazilian Sao Paulo Research FoundationNHLBI NIH HHS K99 HL168211NHLBI NIH HHS P01 HL090554NHLBI NIH HHS R00 HL168211NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389United States National Institutes of Health
6 · The paper itself

Abstract

Fentanyl is widely used perioperatively and illicitly as a drug of abuse. As a potent μ-opioid receptor agonist, fentanyl canonically inhibits excitability through Gα

Indexed as

Analgesics, OpioidFentanylPotassium Channel BlockersAnimalsDiaphragmHumansMaleMiceMice, Inbred C57BLMotor NeuronsReceptors, Opioid, muAnalgesics, OpioidFentanylPotassium Channel BlockersReceptors, Opioid, muEAG K+ channelsfentanylwooden chest syndrome

Identifiers

PMID41110851
PMCPMC13078850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.