ArticlePediatrics2025
Guidelines for Early Food Introduction and Patterns of Food Allergy.
Article in Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Recent Updates in the Management of Anaphylaxis: The Role of the Pediatrician.Journal of pediatrics. Clinical practice · 2026Article
- Optimizing Feeding Practices Improves Outcomes During Early Childhood in Former Small for Gestational Age (SGA) Infants.Nutrients · 2026Article
- The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort.The journal of allergy and clinical immunology. Global · 2026Article
- Incidence and clinical management of paediatric emergency presentations of anaphylaxis in Alberta.Paediatrics & child health · 2026Article
- Implementation of early peanut introduction among providers in a southern US state.The journal of allergy and clinical immunology. Global · 2026Article
- Early Allergen Introduction in Delaware: A Model to Address Healthcare Disparities and Population Healthcare Costs.Cureus · 2026Review
- Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
objectiveWe aimed to determine whether rates of peanut (or any) immunoglobulin E-mediated food allergy (IgE-FA) changed following the publication of early peanut introduction guidelines and/or addendum guidelines.
methodsUsing electronic health record data from the multistate, primary care-based American Academy of Pediatrics Comparative Effectiveness Research through Collaborative Electronic Reporting (CER2) network, we defined preguidelines, postguidelines, and postaddendum guidelines cohorts (cohort entry during September 1, 2012, to August 31, 2014; September 1, 2015, to August 31, 2017; and February 1, 2017, to January 31, 2019, respectively). We determined the cumulative incidence of IgE-FA and/or atopic dermatitis (AD) in children aged 0-3 years, observed for either at least 1 or 2 years. Diagnosis rates during pre- vs postguidelines periods were compared using logistic regression, Cox proportional hazards modeling, and interrupted time series analysis.
resultsThe cumulative incidence and risk of development of peanut IgE-FA (0.79%-0.53%; hazard ratio [HR], 0.65; 95% CI, 0.55-0.77) and any IgE-FA (1.46%-1.02%; HR, 0.69; 95% CI, 0.61-0.78) decreased significantly (P < .0001) from the preguidelines to postguidelines period. Furthermore, the cumulative incidence and risk of development of peanut IgE-FA (0.79%-0.45%; HR, 0.55; 95% CI, 0.46-0.66) and any IgE-FA (1.46%-0.93%; HR, 0.63; 95% CI, 0.55-0.72) decreased significantly (P < .0001) from the preguidelines to postaddendum guidelines period. A decline in IgE-FA diagnosis postguidelines was confirmed in the interrupted time series analysis.
conclusionWe detected decreased rates of peanut or any IgE-FA in the period following the publication of early introduction guidelines and addendum guidelines. Our results are supportive of the intended effect of these landmark public health recommendations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.