Evidence map›Paper›PMID 41110590›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2025

HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage.

Didhiti Deb, Mohammad Eghbal Heidari, Balladiah Kizito, Monamodi Kesamang, Tebogo Matila, Maitshwarelo Matsheka, Stefan Niemann, Sanghyuk S Shin, Chawangwa Modongo

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Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Didhiti DebDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Mohammad Eghbal HeidariSue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA, USA.
Balladiah KizitoVictus Global Botswana Organisation, Gaborone, Botswana.
Monamodi KesamangBotswana Institute for Technology Research and Innovation, Gaborone, Botswana.
Tebogo MatilaVictus Global Botswana Organisation, Gaborone, Botswana; School of Medicine, St. George's University, Saint George's, Grenada.
Maitshwarelo MatshekaBotswana Institute for Technology Research and Innovation, Gaborone, Botswana.
Stefan NiemannResearch Center Borstel, Leibniz Lung Center, Borstel, Germany; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany; EPHE, PSL University, and Institut de Systématique, Evolution, Biodiversité, ISYEB, Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, Paris, France.
Sanghyuk S ShinSue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA, USA. Electronic address: ssshin2@uci.edu.
Chawangwa ModongoVictus Global Botswana Organisation, Gaborone, Botswana.

Funding

Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent settingR01AI147336 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SHIN, SANGHYUK SAM · 2020 to 2024
$3.3M
The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concernR01AI170204 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MODONGO, CHAWANGWA, NIEMANN, STEFAN · 2022 to 2025
$2.4M
NIAID NIH HHS R01 AI147336NIAID NIH HHS R01 AI170204
6 · The paper itself

Abstract

objectivesThis cohort study examined the associations between HIV status with SARS-CoV-2 viral load and duration of infection in a setting with high antiretroviral therapy (ART) coverage.

methodsCOVID-19 patients enrolled from public health clinics in Gaborone, Botswana underwent weekly serial testing for SARS-CoV-2. RT-PCR cycle threshold (Ct) value was used as a proxy measure of viral load. Multiple linear regression and Cox proportional-hazards models were used to determine the associations between HIV with Ct and time to SARS-CoV-2 negativity, respectively.

resultsOf the 486 enrolled participants, 88.7% were vaccinated for COVID-19, and 26.1% were people living with HIV (PLWH) with a mean CD4+ T cell count of 715 cells/µL and 86.6% taking ARTs. Mean Ct values were similar across HIV and CD4+ T cell categories (P = 0.76). Time to negativity was similar for PLWH with CD4+ T cell count ≥500 cells/µL (adjusted hazard ratio [aHR] = 1.00; 95% confidence interval [CI] = 0.61, 1.64) and <500 cells/µL (aHR = 1.24; 95% CI: 0.88, 1.75) compared to people without HIV.

conclusionsIn a setting with well-controlled HIV and high COVID-19 vaccine coverage, HIV status was not associated with SARS-CoV-2 viral load or infection duration.

Indexed as

COVID-19COVID-19 VaccinesHIV InfectionsSARS-CoV-2Viral LoadAdultBotswanaCD4 Lymphocyte CountCohort StudiesFemaleHumansMaleMiddle AgedTime FactorsCOVID-19 VaccinesCD4 cell countCycle threshold valueHuman immunodeficiency virusImmunosuppressionTransmissionViral shedding

Identifiers

PMID41110590
PMCPMC13069993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.