ArticleEnvironment international2025
Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus.
Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age.bioRxiv : the preprint server for biology · 2026Article
- Residential proximity to transport facilities as urban determinants of individual-level per- and poly-fluoroalkyl substance (PFAS) exposures: Analysis of two longitudinal cohorts in Singapore.Environmental health : a global access science source · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundMany environmental chemicals have been shown to cross the placental barrier, threatening the health of offspring. Additionally gestational diabetes mellitus (GDM) may affect the transplacental transfer ratios (TTRs) of environmental chemicals, but the rate of transfer of a wide variety of environmental chemicals have not been widely studied.
objectiveWe examined the TTRs of per- and poly- fluoroalkyl substances (PFAS), phthalates, parabens, bisphenols, and benzophenones in pregnant women, and if GDM increases transplacental transfer of these chemicals.
methodsWe examined 576 mother-newborn pairs from the Growing up in Singapore Towards healthy Outcomes (GUSTO) birth cohort enrolled 2009-2010. Fetal cord plasma to maternal plasma ratios from samples around delivery (TTRs) were estimated for 10 PFAS, 6 phthalates, bisphenol-S (BPS), 2 parabens, and 2 benzophenones. GDM was defined as elevated fasting plasma glucose or 2 h plasma glucose from an oral glucose tolerance test at mid-gestation. We estimated covariate-adjusted associations of GDM with TTRs using multivariable regressions.
resultsMedian TTRs ranged from 0.13 for benzophenone to 2.2 for mono-2-ethylhexyl phthalate. Overall, TTRs were highest for phthalates and short-chain PFAS and lowest for benzophenone and long-chain PFAS. GDM was significantly associated with higher TTRs for perfluorooctanoic, perfluorononanoic, and perfluoroheptanoic acids, BPS, monoethyl phthalate, and oxybenzone. Mothers with GDM had 15% (95% confidence intervals [CI]: 5%, 25%) and 123% (95% CI: 32%, 214%) higher TTRs for oxybenzone and BPS respectively as compared to mothers without GDM.
conclusionsWe found high TTRs for multiple short half-life chemicals and more recently introduced short-chain PFAS. Importantly, GDM was associated with increased transplacental efficiency of several classes of environmental chemicals, particularly chemicals with shorter half-lives.
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