Observational studyJournal of neurology2025
The microlesion effect is associated with global cognitive impairment and predicts motor outcomes after subthalamic deep brain stimulation in Parkinson's disease.
Observational study in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06685510 (The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
Who cites it
1 citing paper in PubMed.
- Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study.CNS neuroscience & therapeutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveA postoperative microlesion effect (MLE) is regarded as a reliable predictor of the subsequent efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) treatment. However, the predictive ability of MLE for postoperative motor improvement after DBS surgery in PD patients with global cognitive impairment (GCI) has not been fully explored.
methodsThis was a prospective, open-label, single-center study with a 6-month follow-up. Patients were divided into three groups based on the MLE response. After separately stratifying by MLE and by global cognitive impairment, we compared postoperative motor symptoms, as assessed by the MDS-UDPRS III, across these strata. To further investigate the impact of global cognitive impairment on long-term postoperative motor outcomes, a mediation analysis was conducted.
resultsThere were 18 patients (40%) classified as the Low MLE group, 19 patients (42.2%) as the Medium MLE group, and 8 patients (17.8%) as the High MLE group. Overall, the interaction effects of Group and Time (P = 0.008) were observed for changes in the MDS-UPDRS III score from baseline. The NC group exhibited a greater improvement compared to the GCI group. Global cognitive impairment was strongly associated with long-term postoperative motor outcomes (P = 0.002), with MLE serving as a mediator (indirect effect = - 0.10, P = 0.042).
interpretationIn summary, our study demonstrated that postoperative MLE is common and has strong predictive value for the efficacy of motor symptoms six months after STN-DBS. Additionally, MLE may partially mediate the detrimental effects on motor outcomes caused by global cognitive impairment. TRIAL REGISTRY: CLINICALTRIALS. GOV IDENTIFIER: NCT06685510.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.