ArticleEuropean journal of pediatrics2025
Pediatric fever of unknown origin: Diagnostic spectrum revealed by a multidisciplinary retrospective study.
Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The etiological spectrum of pediatric FUO and clinical management of PFAPA/SURF: a ten-year retrospective study.Frontiers in immunology · 2026Article
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Authors and funding
14 authors.
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Abstract
Determining the etiology of fever of unknown origin (FUO) often challenges pediatricians. This study aims to evaluate the clinical and laboratory findings, treatments, and etiologies of children diagnosed with FUO, in order to identify early diagnostic approaches for the underlying cause. A retrospective review was conducted on patients aged 0-18 years who were investigated for FUO between April 2021 and April 2024. A total of 90 patients were included. The median age was 53.5 months (2-213), 52.2% were female, 85.6% had no comorbidities, and 96.7% were fully vaccinated. The median total duration of fever was 11 days (8-72). The most common etiologies were infectious (46.7%) and rheumatological diseases (28.9%), and 20% had no identifiable etiology. When comparing patients with fever durations of 8-14 days to those lasting more than 14 days, the latter group had significantly higher leucocytes (10.5 vs 14.6 × 10
conclusionOur study shows that infections are the most common cause of FUO. The notably higher levels of neutrophils, ferritin, and IL-6 in rheumatological diseases suggest their potential utility in early differential diagnosis. WHAT IS KNOWN: • Fever of unknown origin is a clinical and diagnostic dilemma for pediatricians. WHAT IS NEW: • The higher leucocytes in prolonged fever and the notably higher levels of leucocytes, neutrophils, platelets, CRP, ESR, fibrinogen, ferritin, and IL-6 in rheumatological diseases suggest their potential utility in early differential diagnosis.
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