Evidence map›Paper›PMID 41109875›Full record

ArticleAnnals of surgical oncology2026

Survival of Open Versus Thoracoscopic Esophagectomy for Esophageal Squamous Cell Cancer by Tumor Location: An Energy Balancing Weights Analysis.

Yishuo Gao, Yongli Yang, Tongtong Ren, Nana Wang, Peinan Chen, Funa Yang, Xiaocan Jia

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yishuo GaoDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Yongli YangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Tongtong RenDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Nana WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Peinan ChenDepartment of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
Funa YangDepartment of Hospital Infection Control, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
Xiaocan JiaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. jxc@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe survival impact of open esophagectomy (OE) versus thoracoscopic esophagectomy (TE) in patients with esophageal squamous cell carcinoma (ESCC) based on tumor location remains debated. This study employs energy balancing weights (EBW) to compare long-term survival between OE and TE across tumor locations. PATIENTS AND

methodsThis ambispective cohort study analyzed 1778 patients with ESCC undergoing OE or TE at a tertiary hospital between January 2015 and December 2016. Primary endpoints were 5-year overall survival (OS) and disease-free survival (DFS); secondary endpoints included operative safety. EBW-adjusted Cox regression was used to compare long-term survival, with sensitivity analyses via inverse probability of treatment weighting and matching weight methods.

resultsThe median survival times for upper, middle, and lower tumor locations were 60.06, 60.48, and 64.35 months, respectively. Compared with OE, the Cox regression analysis of TE showed that in the upper group, the HR was 0.45 (95% CI 0.27-0.75) for OS and the HR was 0.55 (0.34-0.89) for DFS. In the middle group, theHR was 0.64 (0.48-0.85) for OS and the HR was 0.70 (0.53-0.91) for DFS. And in the lower group, the HR was 0.70 (0.44-1.11) for OS and the HR was 0.67 (0.43-1.04) for DFS. Additionally, TE was associated with reduced blood loss and increased lymph node yield but had longer operative times and higher costs (P < 0.05).

conclusionsTE improved survival and safety in upper/middle ESCC, while lower tumor locations require individualized approaches. EBW enhanced confounder control, supporting reliable clinical decisions.

Indexed as

Carcinoma, Squamous CellEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyThoracoscopyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateEnergy balancing weightsOpen esophagectomySurvival outcomesThoracoscopic esophagectomyTumor location

Identifiers

PMID41109875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.